Originally Posted by Biohaz4rd 
When designing a website in Photoshop, there is a general rule for Anti Aliasing that most should know. The rule states that if the text is 18px or more, you should Anti-Alias, were as if its 16 or less you really shouldn't...
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Pretty much this. It depends on the size of the text. If it's under 13px, I never alti-alias