I used to use HTML-Kit a LOT and I recommend it to anyone who wants something in between a plain text editor and an interactive one that guides you once in a way.

Someone I know from another forum also started using Zend Studio. I hear that it doesn't support multiline search and replace...but it does support regular expressions so you can probably use backreferencing in regular expressions to replace multiple lines.

I'm sticking to Vim, Bluefish, Screem and Jedit